Research
The Liao lab uses genetic, genomic, and immunologic approaches to understand the molecular basis for skin diseases. We apply cutting edge technologies and
computational tools to identify new disease genes, understand disease heterogeneity, and predict medical outcomes. Using a systems biology approach, we integrate data from the genome, epigenome, immunome, and microbiome. See Google Scholar for full set.
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
Nick Dand, Philip E. Stuart, John Bowes, David Ellinghaus, Joanne Nititham, Jake R. Saklatvala, Maris Teder-Laving, Laurent F. Thomas, Tanel Traks, Steffen Uebe, Gunter Assmann, David Baudry, Frank Behrens, Allison C. Billi, Matthew A. Brown, Harald Burkhardt, Francesca Capon, Raymond Chung, Charles J. Curtis, Michael Duckworth, Eva Ellinghaus, Oliver FitzGerald, Sascha Gerdes, Christopher E. M. Griffiths, Susanne Gulliver, Philip S. Helliwell, Pauline Ho, Per Hoffmann, Oddgeir L. Holmen, Zhi-Ming Huang, Kristian Hveem, Deepak Jadon, Michaela Köhm, Cornelia Kraus, Céline Lamacchia, Sang Hyuck Lee, Feiyang Ma, Satveer K. Mahil, Neil McHugh, Ross McManus, Ellen H. Modalsli, Michael J. Nissen, Markus Nöthen, Vinzenz Oji, Jorge R. Oksenberg, Matthew T. Patrick, Bethany E. Perez White, Andreas Ramming, Jürgen Rech, Cheryl Rosen, Mrinal K. Sarkar, Georg Schett, Börge Schmidt, Trilokraj Tejasvi, Heiko Traupe, John J. Voorhees, Eike Matthias Wacker, Richard B. Warren, Rachael Wasikowski, Stephan Weidinger, Xiaoquan Wen, Zhaolin Zhang, BSTOP study group, Estonian Biobank research team, Anne Barton, Vinod Chandran, Tõnu Esko, John Foerster, Andre Franke, Dafna D. Gladman, Johann E. Gudjonsson, Wayne Gulliver, Ulrike Hüffmeier, Külli Kingo, Sulev Kõks, Wilson Liao, Mari Løset, Reedik Mägi, Rajan P. Nair, Proton Rahman, André Reis, Catherine H. Smith, Paola Di Meglio, Jonathan N. Barker, Lam C. Tsoi, Michael A. Simpson, James T. Elder
Nature Communications 2025
Multiomic Analysis of the Gut Microbiome in Psoriasis Reveals Distinct Host‒Microbe Associations
Hsin-Wen Chang, Di Yan, Rasnik Singh, Audrey Bui, Kristina Lee, Alexa Truong, Jeffrey M. Milush, Ma Somsouk, Wilson Liao
JID Innovations 2022
Single Cell Transcriptome and Surface Epitope Analysis of Ankylosing Spondylitis Facilitates Disease Classification by Machine Learning
Samuel Alber, Sugandh Kumar, Jared Liu, Zhi-Ming Huang, Diana Paez, Julie Hong, Hsin-Wen Chang, Tina Bhutani, Lianne S. Gensler, Wilson Liao
Frontiers in Immunology 2022
The Psoriasis Glycome: Differential Expression of Cholesterol Particle Glycans and IgA Glycans Linked to Disease Severity
Emanual Maverakis, William Liakos, Dayoung Park, Forum Patel, Fariha Siddiqui, Muchena J. Kailemia, L. Renee Ruhaak, Alina I. Marusina, Guillaume Luxardi, Johann E. Gudjonsson, Stephanie T.Le, April W. Armstrong, Wilson Liao, Alexander A. Merleev, Carlito B. Lebrilla
Journal of Investigative Dermatology 2022
Combined Single Cell Transcriptome and Surface Epitope Profiling Identifies Potential Biomarkers of Psoriatic Arthritis and Facilitates Diagnosis via Machine Learning
Jared Liu, Sugandh Kumar, Julie Hong, Zhi-Ming Huang, Diana Paez, Maria Castillo, Maria Calvo, Hsin-Wen Chang, Daniel D. Cummins, Mimi Chung, Samuel Yeroushalmi, Erin Bartholomew, Marwa Hakimi, Chun Jimmie Ye, Tina Bhutani, Mehrdad Matloubian, Lianne S. Gensler, Wilson Liao
Frontiers in Immunology 2022
Genome-Wide Association Study of Ustekinumab Response in Psoriasis
William T. Connell, Julie Hong, Wilson Liao
Frontiers in Immunology 2022
Single cell RNA-seq of psoriatic skin identifies pathogenic Tc17 subsets and reveals distinctions between CD8 + T cells in autoimmunity and cancer
Jared Liu, Hsin-Wen Chang, Zhi-Ming Huang, Mio Nakamura, Sahil Sekhon, Richard Ahn, Priscila Munoz-Sandoval, Shrishti Bhattarai, Kristen M. Beck, Isabelle M. Sanchez, Eric Yang, Mariela Pauli, Sarah T. Arron, Wai-Ping Fung-Leung, Ernesto Munoz, Xuejun Liu, Tina Bhutani, Jeffrey North, Anne M. Fourie, Michael D. Rosenblum, Wilson Liao
Journal of Allergy and Clinical Immunology 2021
Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy
Margaret M. Lowe, Haley B. Naik, Sean Clancy, Mariela Pauli, Kathleen M. Smith, Yingtao Bi , Robert Dunstan, Johann E. Gudjonsson, Maia Paul, Hobart Harris, Esther Kim, Uk Sok Shin, Richard Ahn, Wilson Liao, Scott L. Hansen, Michael D. Rosenblum
JCI Insight 2020
The Interaction of LILRB2 with HLA-B Is Associated with Psoriasis Susceptibility
Rebecca L. Yanovsky, Haoyan Chen, Stephen Leslie, Mary Carrington, Wilson Liao
Journal of Investigative Dermatology 2019
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues
Margaret M. Lowe, Ian Boothby, Sean Clancy, Richard S. Ahn, Wilson Liao, David N. Nguyen, Kathrin Schumann, Alexander Marson, Kelly M. Mahuron, Gillian A. Kingsbury, Zheng Liu, Priscila Munoz Sandoval, Robert Sanchez Rodriguez, Mariela L. Pauli, Keyon Taravati, Sarah T. Arron, Isaac M. Neuhaus, Hobart W. Harris, Esther A. Kim, Uk Sok Shin, Matthew F. Krummel, Adil Daud, Tiffany C. Scharschmidt, Michael D. Rosenblum
JCI Insight 2019
Transcriptional programming of normal and inflamed human epidermis at single-cell resolution
Jeffrey B. Cheng, Andrew J. Sedgewick, Alex I. Finnegan, Paymann Harirchian, Jerry Lee, Sunjong Kwon, Marlys S. Fassett, Justin Golovato, Matthew Gray, Ruby Ghadially, Wilson Liao, Bethany E. Perez White, Theodora M. Mauro, Thaddeus Mully, Esther A. Kim, Hani Sbitany, Isaac M. Neuhaus, Roy C. Grekin, Raymond J. Cho
Cell Reports 2018
Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis
Di Yan, Richard Ahn, Stephen Leslie, Wilson Liao
Dermatology and Therapy 2018
Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization
Hsin-Wen Chang, Di Yan, Rasnik Singh, Jared Liu, Xueyan Lu, Derya Ucmak, Kristina Lee, Ladan Afifi, Douglas Fadrosh, John Leech, Kimberly S. Vasquez, Margaret M. Lowe, Michael D. Rosenblum, Tiffany C. Scharschmidt, Susan V. Lynch, Wilson Liao
Microbiome 2018
Network analysis of psoriasis reveals biological pathways and roles for coding and long non-coding RNAs
Richard Ahn, Rashmi Gupta, Kevin Lai, Nitin Chopra, Sarah T. Arron, Wilson Liao
BMC Genomics 2016
Influence of diet on the gut microbiome and implications for human health
Rasnik K. Singh, Hsin-Wen Chang, Di Yan, Kristina M. Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani, Wilson Liao
Journal of Translational Medicine 2017
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
Xianyong Yin, Hui Qi Low, Ling Wang, Yonghong Li, Eva Ellinghaus, Jiali Han, Xavier Estivill, Liangdan Sun, Xianbo Zuo, Changbing Shen,Caihong Zhu, Anping Zhang, Fabio Sanchez, Leonid Padyukov, Joseph J. Catanese, Gerald G. Krueger, Kristina Callis Duffin, Sören Mucha, Michael Weichenthal, Stephan Weidinger,Wolfgang Lieb, Jia Nee Foo, Yi Li, Karseng Sim, Herty Liany, Ishak Irwan, Yikying Teo, Colin T. S. Theng, Rashmi Gupta, Anne Bowcock, Philip L. De Jager, Abrar A. Qureshi, Paul I. W. de Bakker, Mark Seielstad, Wilson Liao, Mona Ståhle, Andre Franke, Xuejun Zhang, Jianjun Liu
Nature Communications 2015
Influence of HLA-C expression level on HIV control
Richard Apps, Ying Qi, Jonathan M. Carlson, Haoyan Chen, Xiaojiang Gao, Rasmi Thomas, Yuko Yuki, Greg Q. Del Prete, Philip Goulder, Zabrina L. Brumme, Chanson J. Brumme, Mina John, Simon Mallal, George Nelson, Ronald Bosch, David Heckerman, Judy L. Stein, Kelly A. Soderberg, M. Anthony Moody, Thomas N. Denny, Xue Zeng, Jingyuan Fang, Ashley Moffett, Jeffrey D. Lifson, James J. Goedert, Susan Buchbinder, Gregory D. Kirk, Jacques Fellay, Paul McLaren, Steven G. Deeks, Florencia Pereyra, Bruce Walker, Nelson L. Michael, Amy Weintrob, Steven Wolinsky, Wilson Liao, Mary Carrington
Science 2013
Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease
Haoyan Chen, Genki Hayashi, Olivia Y. Lai, Alexander Dilthey, Peter J. Kuebler, Tami V. Wong, Maureen P. Martin, Marcelo A. Fernandez Vina, Gil McVean, Matthias Wabl, Kieron S. Leslie, Toby Maurer, Jeffrey N. Martin, Steven G. Deeks, Mary Carrington, Anne M. Bowcock, Douglas F. Nixon, Wilson Liao
PLOS Genetics 2012
A Genetic Risk Score Combining Ten Psoriasis Risk Loci Improves Disease Prediction
Haoyan Chen, Annie Poon, Celestine Yeung, Cynthia Helms, Jennifer Pons, Anne M. Bowcock, Pui-Yan Kwok, Wilson Liao
PLOS ONE 2011