Research

 

The Liao lab uses genetic, genomic, and immunologic approaches to understand the molecular basis for skin diseases. We apply cutting edge technologies and computational tools to identify new disease genes, understand disease heterogeneity, and predict medical outcomes. Using a systems biology approach, we integrate data from the genome, epigenome, immunome, and microbiome.  See Google Scholar for full list.

Single cell RNA-seq of psoriatic skin identifies pathogenic Tc17 subsets and reveals distinctions between CD8 + T cells in autoimmunity and cancer

Jared Liu, Hsin-Wen Chang, Zhi-Ming Huang, Mio Nakamura, Sahil Sekhon, Richard Ahn, Priscila Munoz-Sandoval, Shrishti Bhattarai, Kristen M. Beck, Isabelle M. Sanchez, Eric Yang, Mariela Pauli, Sarah T. Arron, Wai-Ping Fung-Leung, Ernesto Munoz, Xuejun Liu, Tina Bhutani, Jeffrey North, Anne M. Fourie, Michael D. Rosenblum, Wilson Liao

 

Journal of Allergy and Clinical Immunology 2021

Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy

Margaret M. Lowe, Haley B. Naik, Sean Clancy, Mariela Pauli, Kathleen M. Smith, Yingtao Bi , Robert Dunstan, Johann E. Gudjonsson, Maia Paul, Hobart Harris, Esther Kim, Uk Sok Shin, Richard Ahn, Wilson Liao, Scott L. Hansen, Michael D. Rosenblum

 

JCI Insight 2020

The Interaction of LILRB2 with HLA-B Is Associated with Psoriasis Susceptibility

Rebecca L. YanovskyHaoyan ChenStephen LeslieMary CarringtonWilson Liao

Journal of Investigative Dermatology 2019
 

 

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues

Margaret M. Lowe, Ian Boothby, Sean Clancy, Richard S. Ahn, Wilson Liao, David N. Nguyen, Kathrin Schumann, Alexander Marson, Kelly M. Mahuron, Gillian A. Kingsbury, Zheng Liu, Priscila Munoz Sandoval, Robert Sanchez Rodriguez, Mariela L. Pauli, Keyon Taravati, Sarah T. Arron, Isaac M. Neuhaus, Hobart W. Harris, Esther A. Kim, Uk Sok Shin, Matthew F. Krummel, Adil Daud, Tiffany C. Scharschmidt, Michael D. Rosenblum

JCI Insight 2019
 

Transcriptional programming of normal and inflamed human epidermis at single-cell resolution

Jeffrey B. ChengAndrew J. SedgewickAlex I. FinneganPaymann HarirchianJerry Lee,  Sunjong KwonMarlys S. FassettJustin GolovatoMatthew GrayRuby Ghadially, Wilson LiaoBethany E. Perez WhiteTheodora M. MauroThaddeus MullyEsther A. KimHani Sbitany,  Isaac M. NeuhausRoy C. Grekin, Raymond J. Cho

Cell Reports 2018
 

Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis

Di Yan, Richard Ahn, Stephen Leslie, Wilson Liao 

Dermatology and Therapy 2018
 

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization

Hsin-Wen Chang, Di Yan, Rasnik Singh, Jared Liu, Xueyan Lu, Derya Ucmak, Kristina Lee, Ladan Afifi, Douglas Fadrosh, John Leech, Kimberly S. Vasquez, Margaret M. Lowe, Michael D. Rosenblum, Tiffany C. Scharschmidt, Susan V. Lynch, Wilson Liao 

Microbiome 2018
 

Network analysis of psoriasis reveals biological pathways and roles for coding and long non-coding RNAs

Richard Ahn, Rashmi Gupta, Kevin Lai, Nitin Chopra, Sarah T. Arron, Wilson Liao 

BMC Genomics 2016
 

Influence of diet on the gut microbiome and implications for human health

Rasnik K. Singh, Hsin-Wen Chang, Di Yan, Kristina M. Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani, Wilson Liao

Journal of Translational Medicine 2017

Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility

Xianyong YinHui Qi LowLing WangYonghong LiEva EllinghausJiali HanXavier EstivillLiangdan SunXianbo ZuoChangbing Shen,Caihong ZhuAnping ZhangFabio SanchezLeonid PadyukovJoseph J. CataneseGerald G. KruegerKristina Callis DuffinSören MuchaMichael WeichenthalStephan Weidinger,Wolfgang LiebJia Nee FooYi LiKarseng SimHerty LianyIshak IrwanYikying TeoColin T. S. ThengRashmi GuptaAnne BowcockPhilip L. De JagerAbrar A. QureshiPaul I. W. de BakkerMark SeielstadWilson LiaoMona StåhleAndre FrankeXuejun Zhang, Jianjun Liu

 

Influence of HLA-C expression level on HIV control

Richard AppsYing Qi, Jonathan M. Carlson, Haoyan Chen, Xiaojiang Gao, Rasmi Thomas, Yuko Yuki, Greg Q. Del Prete, Philip Goulder, Zabrina L. Brumme, Chanson J. Brumme, Mina John, Simon Mallal, George Nelson, Ronald Bosch, David Heckerman, Judy L. Stein, Kelly A. Soderberg, M. Anthony Moody, Thomas N. Denny, Xue Zeng, Jingyuan Fang, Ashley Moffett, Jeffrey D. Lifson, James J. Goedert, Susan Buchbinder, Gregory D. Kirk, Jacques Fellay, Paul McLaren, Steven G. Deeks, Florencia Pereyra, Bruce Walker,​​​​​ Nelson L. MichaelAmy WeintrobSteven WolinskyWilson LiaoMary Carrington

Science 2013

Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease

Haoyan Chen, Genki Hayashi, Olivia Y. Lai, Alexander Dilthey, Peter J. Kuebler, Tami V. Wong, Maureen P. Martin, Marcelo A. Fernandez Vina, Gil McVean, Matthias Wabl, Kieron S. Leslie, Toby Maurer, Jeffrey N. Martin, Steven G. Deeks, Mary Carrington, Anne M. Bowcock, Douglas F. Nixon, Wilson Liao

PLOS Genetics 2012

A Genetic Risk Score Combining Ten Psoriasis Risk Loci Improves Disease Prediction

Haoyan Chen, Annie Poon, Celestine Yeung, Cynthia Helms, Jennifer Pons, Anne M. Bowcock, Pui-Yan Kwok, Wilson Liao

 
PLOS ONE 2011